Objective To  investigate  the clinical  significance of hepatocellular carcinoma  (HCC) group’s cellular  immunity function. Methods Fifty  four cases of HCC group and 24 cases of control group were enrolled in our study. Detected their peripheral blood CD4+, CD8+, T-lymphocyte with APAAP, AFP and liver function,  respectively. Results CD4+ and CD4+/CD8+ of  the HCC group were obviously  lower  than control group (P ＜ 0.05), and CD8+ is more than control group. There were 18 cases of portal cancer embolus in 54 cases of HCC group, T-lymphocytes subset signiicantly  lower  than 36 cases of non-portal cancer embolus (P ＜ 0.05). For  the merger of  liver cirrhosis or not and different  levels of AFP with T-lymphocytes subset had not statistical signiicance. Conclusions Cellular immunity function of HCC group is worse than that of control group, and it has correlate with invasive activity of tumor cell.