Objective To observe  the protective effectiveness of Shuganning  injection on hepatic  injury caused by chemotherapy drug. Methods Total of 46 patients with  tumors who had  slight hepatic  injury after chemotherapy were  randomly divided  into  treatment group and control group.  In  treatment group, Shuganning was additionally added by intravenous infusion to 26 patients. However, the other 20 patients in control group were given routine liver-protective drugs only. The change of ALT was researched before and after therapy to test the effectiveness of Shuganning injection. Results The serum level of ALT in treatment group was obviously lower than that of control group, the difference was signiicant (P ＜ 0.05). Conclusions Shuganning injection has noticeable effect to relieve hepatic injury caused by chemotherapy.