Objective To objective  the  clinical  effect of  the  combination  therapy of promethazine  and pantoprazple on  the patients with hepatic cirrhosis complicated with hiccup. Methods On  the basis of general  therapy, 35 patients with hepatic cirrhosis complicated with hiccup, were given  intravenous drip of pantoprazple, 40 mg,  inferferon, promethazine, 25 mg, each  time one day, 3 days as a corse. Results The hiccup of 35 patients stopped  in 2 days after  the combination  therapy, only one patient  recurred one month later, the total effective treatment rate was 100%. Conclusions The clinical effect of the combination therapy promethazine and pantoprazple on the patients with hepatic cirrhosis complicated with hiccup was signiicant.