Objective To observe  the effect of Silybin capsules for chronic hepatitis B (CHB). Methods Eighty patients of CHB were divided into therapeutic group and control group randomly, of whom 56 patients in therapeutic group with Silybin capsule, 24 patients in control group with protect liver tablets. The change of clinical effect, symptom improving, ALT, AST, TBil and adverse effect. Results The total effective rate and symptom normalization of  therapeutic group  improved signiicantly  than  that of control group (P ＜ 0.05). ALT, AST and TBil of  two groups decreased signiicantly after  treatment (P ＜ 0.05). TBil of  therapeutic groups decreased signiicantly  than  that of control group (P ＜ 0.05). There are no signiicant differences  in negative rate of virus between two groups (P ＞ 0.05). There are no adverse effect in treatment. Conclusions Silybin can encourage  to  repair  liver cells, and  to prevent necrosis of  them. Some clinical utilized value  in using Silybin capsules had been showed in treating chronic hepatitis B effectively.