中国肝脏病杂志(电子版)

位置：首页 >> 期刊文章

艾滋病并发脂肪肝患者HAART治疗后左心室结构及功能变化

作者：肖江郜桂菊李鑫韩宁王凌航刘龙杨涤张黎颖赵红心毛羽

分类号：

出版年,卷(期):页码：2010,2(4):7-11

摘要：

目的使用超声心动图检测艾滋病并发非酒精性脂肪肝（NAFLD）患者长期高效抗反转录病毒治疗后左心室结构和功能变化。方法本研究以高效抗反转录病毒治疗后高脂血症作为切入点，检测42例高效抗反转录病毒治疗后高脂血症患者的体重指数（BMI）、血压、高效抗反转录病毒治疗时间、CD4细胞水平、空腹血脂水平，完善腹腔彩色超声检查，通过彩色超声发现艾滋病患者脂肪肝变化；通过超声心动图检测左心室结构、收缩和舒张功能变化。结果 42例艾滋病患者中，NAFLD患者共28例，占66.7%；NAFLD组患者BMI（23.61 ± 2.55）㎏/㎡，非脂肪肝组BMI（22.06 ± 1.96）㎏/㎡。NAFLD组中，晚期血流充盈速度（A值）为（55.61 ± 13.12）㎝/s、E/A比值为（1.19 ± 0.29）；非脂肪肝组A值为（43.36 ± 10.88）㎝/s、E/A比值为（1.65 ± 0.41），两组间差异有统计学意义。NAFLD组和非脂肪肝组中，左室结构参数和左室射血分数无显著性差异；但左室短轴收缩率分别为（34.67 ± 4.92）%和（38.14 ± 7.27）%，P = 0.07。结论艾滋病并发NAFLD患者长期高效抗反转录病毒治疗后出现左室舒张功能不全，收缩功能亦出现一定程度降低，应定期完善心脏彩色超声检查，警惕心血管事件发生。

Objective To study the changes of left ventricular structure and functions in AIDS patients with NAFLD after long-term HAART treatment. Methods Clinical data of 42 cases of AIDS patients complicated with hyperlipidemia were collected and studied, retrospectively. Indexes of BMI, blood pressure, durations of HAART treatments, fasting serum lipid, CD4 counts were focused on. Ultrasound scan imaging was applied to detect hepatic steatosis. The changes of left ventricular structure and functions were explored by color Doppler echocardiography. Results Prevalence of NAFLD in AIDS patients after HAART treatment was 66.7%. In AIDS patients with NAFLD, BMI was (23.61 ± 2.55)㎏/㎡, peak velocity at late diastole (A value) was (55.61 ± 13.12) ㎝/s and E/A ratio was (1.19 ± 0.29)；while in non-NAFLD patients, BMI was (22.06 ± 1.96)㎏/㎡, A value was (43.36 ± 10.88) ㎝/s and E/A ratio was (1.65 ± 0.41), respectively. Conclusions Left ventricular diastolic dysfunction were found in AIDS patients with NAFLD after long-term HAART and the systolic function decreased in some degree in these patients.

基金项目：

十一五重大专项“艾滋病机会性感染及减少HAART毒副反应的中医药治疗方案/方法的研究”（2008ZX10005-003）

作者简介：

参考文献：

服务与反馈：

【文章下载】【加入收藏】