Abstract: Objective To observe the clinical effects of Liuweiwuling tablets on liver injury and antivirus in chronic hepatitis B patients. Methods Methods Total of 78 chronic hepatitis B patients were randomly divided into treatment group (46 cases) and control group (32 cases), which received Liuweiwuling tablets combined with adefovir dipivoxil (ADV) and bifendate pills combined with ADV, respectively. Both groups were treated for eight months. The liver function and HBV DNA undetectable ratio were analyzed. Results The liver function recovery rate and HBV DNA undetectable ratio of treatment group were better than control group (P ＜ 0.05). Conclusions Liuweiwuling tablets has a great effect on decreasing aminotransferase, liver function protection, and hepatitis B virus inhibiting for chronic hepatitis B patients.