Abstract: Objective To assess the therapeutic effect of silymarin combined with simvastatin on patients with nonalcoholic steatohepatitis.  nonalcoholic steatohepatitis. Methods Total of 70 patients with non-alcoholic steatohepatitis were randomly divided into experiment group treated with silymarin combined with simvastatin (n = 35) and control group divided into experiment group treated with liverprotecting tablet and Vitamine E (n = 35), respectively for consecutive 12 weeks. Serum transaminase levels, triglyceride, cholesterol were detected before and after treatment, respectively. Side-effect was also observed during the therapy. Results The levels of serum ALT both in experiment group and control group were obviously reduced at the end point compared with the base line, especially in the former group (P ＜ 0.05); the disturbance of TG, TC were all markedly ameliorated in experiment group compared with control group after treatment, and no severe side-effects occurred during the therapy. Conclusions Silymarin combined with simvastatin is an effective and safe remedy for patients with non-alcoholic steatohepatitis.