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硫化氢及一氧化氮在非酒精性脂肪性肝病患者血浆中的变化

作者：郑艳丽谢杏榕谭华炳李金科李芳雷飞飞

单位：1. 湖北医药学院附属人民医院感染性疾病科十堰市 442000 2. 湖北房县中医院十堰市 442100

关键词：脂肪肝酒精性硫化氢一氧化氮血浆甘油三酯类

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出版年,卷(期):页码：2011,3(4):1-4

摘要：

摘要：目的探讨硫化氢（H2S）、一氧化氮（NO）在非酒精性脂肪性肝病（NAFLD）发病中的作用。方法 45例确诊的NAFLD患者，根据脂肪肝程度分为轻度组（A组）、中度组（B组）、重度组（C组）。选择20例同期健康体检正常者为对照组（D组）。全部标本同步检测血甘油三酯（TG）、胆固醇（TC）、NO及H2S水平。结果 A、B、C组H2S水平分别为（22.78 ± 3.23）μmol/L、（17.98 ± 2.67）μmol/L、（12.57 ± 2.12）μmol/L，与D组（29.13 ± 4.47）μmol/L相比均显著下降，差异有统计学意义（A组与D组比较，P ＜ 0.05；B、C组与D组比较，P ＜ 0.01）。C组H2S水平低于B组，B组H2 组H 组H S水平低于A组，差异有统计学意义（P ＜ 0.05）。A、B、C组血NO水平分别为（42.45 ± 6.12）µmol/L、（54.77 ± 5.99）µmol/L、（69.23 ± 6.33）µmol/L，与D组（29.23 ± 3.97）µmol/L相比均显著上升，差异有统计学意义（P ＜ 0.01）。C组NO水平高于B组，B组NO水平高于A组，差异有统计学意义（P ＜0.05）。A、B、C组TG水平分别为（2.45 ± 0.94）mmol /L 、（2.99 ± 0.89）mmol /L、（3.87 ± 1.13）mmol /L，与D组（1.63 ± 0.24）mmol/L相比均显著上升，差异有统计学意义（P ＜ 0.01）。C组TG水平高于B组，B组TG水平高于A组，差异有统计学意义（P ＜ 0.05）。A、B、C组TC水平分别为（9.99 ± 1.46 ）mmol/L 、（10.13 ± 1.99）mmol/L、（10.24 ± 2.21 ）mmol/L，与D组（5.44 ± 0.78）mmol/L相比均显著上升，差异有统计学意义（P ＜ 0.01）。A、B、C组间TC水平比较，差异无统计学意义（P ＞ 0.05）。结论 H2S、NO与NAFLD的发生、发展相关，非酒精性脂肪性肝病程度与TG密切相关。

Abstract: Objective To explore the effect of hydrogen sulfide (H2S) and nitric oxide (NO) in the morbidity of nonalcoholic fatty liver disease (NAFLD). Methods Total of 45 patients with NAFLD were divided into group A (mild group), group B (moderate group) and group C (severe group). Group D (20 cases) were normal healthy person in the same period. Triglyceride (TG), total cholesterol (TC), NO and H2S were detected. Results H2S levels in group A, B and C were (22.78 ± 3.23) μmol/L, (17.98 ± 2.67) μmol/L and (12.57 ± 2.12) μmol/L, respectively, which were significantly lower than group D (29.13 ± 4.47) μmol/L both with significant differences (P ＜ 0.05, P ＜ 0.01). The differences were significant between group A, B and C (P ＜ 0.05). NO levels in group A, B and C were (42.45 ± 6.12) µmol/L, (54.77 ± 5.99) µmol/L and (69.23 ± 6.33) µmol/L, respectively, which were significantly higher than group D (29.23 ± 3.97) µmol/L both with significant differences (P ＜ 0.01). There were significant differences between group A, group B and group C (P ＜ 0.05). TG levels in group A, B and C were (2.45 ± 0.94)mmol/L, (2.99 ± 0.89) mmol/L and (3.87 ± 1.13) mmol/L, respectively, which were higher compared with group D (1.63 ± 0.24) mmol/L with significant differences (P ＜ 0.01). The differences were significant between group A, B and C (P ＜ 0.05). TC levels in group A, B and C were (9.99 ± 1.46) mmol/L, (10.13 ± 1.99) mmol/L and (10.24 ± 2.21) mmol/L, respectively, which were higher than group D (5.44 ± 0.78) mmol/L. The differences were statistically signi? cant (P ＜ 0.01). There was no difference between group A, B and C (P ＞ 0.05). Conclusions H2S and NO were related to the occurrence and development of NAFLD.

基金项目：

湖北省教育厅科技项目（D20102104），湖北省卫生厅科研项目（JX5B75），十堰市科技局科技项目（2010st33）， 2010年湖北医药学院学生科研项目(2010XSA19)

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