Abstract: Objective To observe the characteristics of hepatic pathology of patients with chronic hepatitis B during the immune tolerant phase. Methods Total of 112 patients with chronic hepatitis B during the immune tolerant phase were analyzed, retrospectively. Combined with previous clinical research, liver tissue inflammation, fibrosis stage and distribution types of HBcAg by immunohistochemistry were discussed. Results The  infiammation grades were G0 in 31 cases, G1 in 75 cases, G2 in 4 cases, G3～4 in 2 cases. The fibrosic stages were S0 in 34 cases, S1 in 63 cases, S2 in 9 cases, S3～4 in 6 cases. The distribution type of HBcAg by immunohistochemistry was 48 cases of nuclei type, 53 cases of mixed type, 4 cases of cytoplasm type and 7 negative cases. The difference of pathlogical characteristics among gender, age, subgroups (ALT less than 40 U/L) were not statistically significant  (χ2 = 0.50, 2.62, 1.22; P ＞ 0.05). Conclusions Patients during immune tolerant phase  (HBV DNA ＞ 107 copies/ml) focuses on young people. The infiammation grades and fibrosic stages were minor. HBcAg mainly distributes in nuclei or mixed types. The difference of pathlogical characteristics among gender, age, subgroups (ALT ≤ 40 U/L) were not statistically significant.