Abstract: Objective To explore the methods, safety and clinical results of argon-helium cryoablation therapy on liver carcinoma. Methods Total of 180 cases with liver carcinoma were selected to undergo argon-helium cryoablation therapy under ultrasound guidance and received periodic reviews of carcinoma marker and CT or MRI following up. Results Eighty five percent of 135 patients with small liver carcinoma (≤ 5 cm) were in complete necrosis after therapy. Among the 45 patients with large hepatocellular carcinoma, all AFP reached  the normal range, 21 (48.6% of the total samples) were in complete tumor necrosis with the proof of CT or MRI examinations. CT or MRI proved that 30 of 44 (68.2%) patients with metastatic hepatic carcinoma were in complete necrosis after therapy. Conclusions Argon-helium cryoablation therapy under ultrasound guidance is safe and effective.