Abstract: Objective To investigate the clinical effect of Liuweiwuling tablets on nonalcoholic steatohepatitis (NASH). Methods Total of 67 cases with NASH were randomly divided into treatment group  (n = 35) and control group (n = 32). Both groups received basic therapy, and the treatment group were added  with Liuweiwuling tablets (1.5 g) three times a day orally. The course of treatment was 12 weeks. The clinical symptoms, physical sign, liver function indexes, blood lipids levels, degree of fatty liver and total effective rate were observed after therapy. Results The clinical symptoms, liver  function, blood lipids levels of two groups improved compared with pre-therapy. All the indexes of  treatment group were better than that of the control group, and  there was significant differences between the two groups (P ＜ 0.05). Conclusions Liuweiwuling tablets can recover liver function, alleviate the clinical symptoms, and has a positive effect on treating non-alcoholic steatohepatitis.