中国肝脏病杂志(电子版)

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肝硬化患者凝血功能检测分析

作者：黄鹤聂庆东张秀梅

单位：清华大学医院检验科北京 100084

关键词：肝硬化凝血酶原时间凝血酶时间纤维蛋白原

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出版年,卷(期):页码：2011,3(4):32-34

摘要：

摘要：目的分析肝硬化患者凝血指标随肝功能损害程度的变化，并探讨其临床意义。方法测定肝硬化组（50例）和对照组（40例）血浆凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）和纤维蛋白原（FIB）。结果肝硬化组凝血指标与对照组比较，PT、APTT、TT均明显延长，差异有显著统计学意义（P ＜ 0.01），FIB明显下降，差异有统计学意义（P ＜ 0.05）。肝硬化失代偿组PT、APTT、TT及FIB与代偿组比较，差异有显著统计学意义（P ＜ 0.01）。结论凝血指标可以客观准确的评价肝硬化患者的凝血功能，能够发现早期肝病造成的凝血机制障碍，对肝硬化出血患者的抢救和治疗具有重要意义。

Abstract: Objective To analyze the effect of coagulation function changes depending on the degree of liver damage in patients with liver cirrhosis. Methods To assay prothrombin time (PT), partial thromboplastin time (APTT), Thrombin time (TT) and Fibrinogen (FIB) in liver cirrhosis group (50 cases) and control group (40 cases). Results PT, APTT and TT of liver cirrhosis group were better than that in control group (P ＜ 0.01), and the FIB was distinctly dropped than that in control group (P ＜ 0.05). PT, APTT, TT and FIB of compensated liver cirrhosis group were better than that in decompensated liver cirrhosis group (P ＜ 0.01). Conclusions The coagulation indicators can objectively and accurately evaluate the coagulation function of patients with liver cirrhosis, which can find earlier coagulation mechanism disorders caused by liver disease. It has important significance to rescue and treat patients with liver cirrhosis when hemorrhage happened.

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