Abstract: Objective To observe the therapeutic effect of silymarin on cases with alcoholic fatty liver. Methods Total of 90 cases with alcoholic fatty liver were randomly divided into treatment groups (45 cases) and control groups (45 cases), oral administration of silybin capsules and oral reduced glutathione were taken for treatment and control group, respectively, with the treatment course as12 weeks and guidence of daily life is strengthened. Results Total effective rate in the treatment group was (86.7%), the control group was (46.7%), with signififificant difference (P ＜ 0.01). Conclusions Silibinin capsule has a positive curative effect on liver function recovery and blood lipids for alcoholic fatty liver patients, which signifi cantly better than the control group, with good effi cacy and application security.