Abstract: Objective To observe the preventive effect of Liuweiwuling tablets for anti-TB medicationsinduced liver injury. Methods Total of 30 patients with pulmonary tuberculosis were randomly divided into the treatment group (n = 15) and control group (n = 15), all patients received “2HRZE(S)/4HR” therapeutic schedule. Meanwhile, the treatment group added Liuweiwuling tablets and the control group added glucurolactone tablet. The incidences of liver injury in both groups were observed during the treatment process. Results The incidence of liver injury was 6.7% (1/15) in the treatment group, which was 26.7% in the control group. There was statistically significant differences between the two groups (P ＜ 0.01). Conclusions Liuweiwuling tablets can effectively prevent and treat anti-TB medications-induced liver injury.