Abstract: Objective To investigate the effect and safety of polyene phosphatidyl choline combined with lipid-lowering drugs in treatment of nonalcoholic fatty liver disease. Methods Total of 103 patients with nonalcoholic fatty liver disease were selected and divided randomly into two groups. In therapeutic group, the patients received polyene phosphatidyl choline combined with simvastatin (n = 55) for 12 weeks. While in control group, the patients received simvastatin, Vitamin C and inosine (n = 48) for 12 weeks. The levels of serum transaminase, clinical symptom, blood grease and image changes of B ultrasonic before and after treatment were compared, respectively. Results The levels of serum transaminase, clinical symptom, blood grease and image changes of B ultrasonic improved obviously after treatment, with the efficiency as 87.3% and 52.1% in therapeutic group and control group, respectively. There were significant difference between the two groups on the improvement of clinical symptome, liver function and blood fat (P ＜ 0.05). ConclusionsTreatment of nonalcoholic fatty liver disease with simvastatin combined with polyene phosphatidyl choline is safe and effective.