Abstract: Objective To evaluate the clinical curative effect of Liuweiwuling tablets in the treatment of hepatic lesion caused by antituberculotic agents. Methods Total of 72 cases with hepatic lesion caused by antituberculotic agents were randomly divided into the treatment group (n = 38) and control group (n = 34). The treatment group was given antituberculotic agents combined with Liuweiwuling tablets. The control group was given antituberculotic agents combined with Hugan tablets. The course of treatment was 4 weeks. All patients were followed-up for 2 weeks after the treatment. And liver function were observed after therapy. Results After the treatment, ALT, AST, TBil levels of the treatment group were better than that of the control group. Conclusions Liuweiwuling tablets can recover liver function and relieve the liver inflammation. It is effective on the treatment of hepatic lesion caused by antituberculotic agents.