Abstract: Objective To observe the effect of clinical nursing pathway (CNP) in perioperative health education on patients with chronic liver disease and protrasion of lumbar intervertebral disci. Methods Total of 63 patients with chronic liver disease and protrasion of lumbar intervertebral disci were randomly divided into experimental group (32 cases) and control group (31 cases). Control group received traditional health education model, and the experimental group received clinical nursing pathway for health education. Results The success rate of health education and degree of satisfaction in the experimental group were significantly higher than those of the control group (P ＜ 0.05). The incidence rate of complications between two groups was statistically significant (P ＜ 0.05). Conclusions The application of clinical nursing pathway can improve the success rate of health education and the degree of satisfaction of patients, which can help to improve the quality of nursing and is an important guarantee for the rehabilitation of patients with lumbar disc herniation and chronic liver disease.