Abstract: Objective To analyze the clinicopathologic characteristics, imaging features and treatment strategies  of  patients  with  focal  nodular  hyperplasia  of  liver  (FNH).  Methods The  clinicopathologic characteristics, diagnosis, therapy and prognosis of 71 patients with FNH were retrospectively analyzed and the related literatures were reviewed. Results Among the 71 patients, 43 were male and 28 were female, with the average age of 37 years old (13-53 years old). There were 33 cases had clinical manifestations including abdominal discomfort, abdominal mass and fatigue. The lesions of 40 patients lied in the left lobe of liver, 27 in right lobe and 4 in both. There were 6 cases with multiple foci. The median tumor diameter was 4.0 cm (0.8-14.0 cm). The diagnostic accuracies of ultrasound, enhanced CT scan and enhanced MR scan were 19.7%, 61.9% and 77.3%, respectively. All the 71 patients underwent surgical operation and no obvious postoperative complications were observed. Conclusions Combination of various imaging methods is beneficial to the improvement of diagnosis of FNH. Sugical management should be offered to patients with clinical manifestations, ambiguous diagnosis or tumor growth. Surgical resections including laparoscopic liver resection are safe and effective for FNH patients.