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慢性乙型肝炎患者HBV DNA载量与肝组织炎症及纤维化程度的相关性分析

作者：汤磊郜玉峰叶珺邹桂舟

单位：安徽医科大学第二附属医院肝病科合肥 230601

关键词：肝硬化肝炎乙型慢性肝炎e抗原乙型

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出版年,卷(期):页码：2013,5(3):1-4

摘要：

摘要：目的研究慢性乙型肝炎（CHB）患者血清HBV DNA载量与肝组织炎症及纤维化程度间的相关性。方法将169例CHB患者根据血清HBeAg分为HBeAg阳性组（110例）和HBeAg阴性组（59例），回顾性分析血清HBV DNA载量与肝组织病理炎症分级、纤维化分期之间关系。结果 HBeAg阳性组与HBeAg阴性组血清HBV DNA 载量分别为（6.9 ± 1.3）log10拷贝/ml和（4.7 ± 1.8）log10拷贝/ml，两组比较差异有统计学意义（P = 0.024）。HBeAg阳性组患者肝组织炎症活动度G1组为9例、G2组为80例、G3～4组为21 例，其血清HBV DNA 载量分别为（5.7 ± 1.4）log10拷贝/ml、（6.4 ± 1.8）log10拷贝/ml、（7.2 ± 1.1）log10拷贝/ml，3组患者血清HBV DNA 载量比较，差异无统计学意义（P = 0.069）。肝组织纤维化程度S1组为28 例、S2组为50例、S3～4组为32例，其血清HBV DNA 载量分别为（6.9 ± 1.1）log10拷贝/ml、（6.9 ± 1.4）log10拷贝/ml、（6.8 ± 4.2）log10拷贝/ml，3组患者血清HBV DNA 载量比较，差异无统计学意义（P = 0.079）。HBeAg阴性组患者肝组织炎症活动度G1组为6 例、G2组为19例、G3～4组为34例，其血清HBV DNA载量分别为（2.2 ± 1.9）log10拷贝/ml、（4.9 ± 1.5）log10拷贝/ml、（5.4 ± 1.8）log10拷贝/ml，3组患者血清HBV DNA载量比较，差异有统计学意义（P = 0.014）；肝组织纤维化程度S1组为12 例、S2组为30 例、S3～4组为17 例，其血清HBV DNA载量分别为（2.6 ± 4.1）log10拷贝/ml、（5.3 ± 1.3）log10拷贝/ml、（5.6 ± 1.7）log10拷贝/ml，3组血清HBV DNA载量比较，差异有统计学意义（P = 0.026）。结论 HBeAg阳性CHB患者血清HBV DNA载量与肝组织炎症及纤维化程度无显著相关。HBeAg阴性CHB患者血清HBV DNA载量较高者，其肝组织炎症及纤维化程度较高。

Abstract: Objective To investigate the correlation between serum HBV DNA level and liver tissue inflammation and fibrosis degrees in the patients with chronic hepatitis B (CHB). Methods The relationship between HBV DNA loads, liver histological inflammation grades and fibrosis stages of 169 cases was analyzed. Results The serum HBV DNA loads in HBeAg-positive group with inflammation grade G1 group (9 cases), G2 group (80 cases) and G3～4 group (21 cases) were (5.7 ± 1.4) log10 copies/ml, (6.4 ± 1.8) log10 copies/ml and (7.2 ± 1.1) log10 copies/ml, respectively. There was no significant differences among patients of three inflammation grades (P = 0.069). The serum HBV DNA loads in HBeAg-positive group with liver tissues fibrosis stages of S1 group (28 cases), S2 group (50 cases), S3～4 group (32 cases) were (6.9 ± 1.1) log10 copies/ml, (6.8 ± 4.2) log10 copies/ml, (6.9 ± 1.4) log10 copies/ml, respectively, with no significant differences (P = 0.079). The serum HBV DNA loads in HBeAg-negative group with inflammation grades G1 group (6 cases), G2 group (19 cases) and G3～4 group (34 cases) were (2.2 ± 1.9) log10 copies/ml, (4.9 ± 1.5) log10 copies/ml, (5.4 ± 1.8) log10 copies/ml, respectively. There was significant differences among the three groups (P = 0.014). The serum HBV DNA loads in HBeAg-negative group with liver tissues fibrosis stages of S1 group (12 cases), S2 group (30 cases), S3～4 group (17 cases) were (2.6 ± 4.1) log10 copies/ml, (5.3 ± 1.3) log10 copies/ml, (5.6 ± 1.7) log10 copies/ml, respectively, with no significant difference (P = 0.026). Conclusions The serum HBV DNA level was not significantly correlated with the inflammation grades and fibrosis stages of liver tissues in HBeAg-positive patients which display a positive correlation in HBeAg-negative patients.

基金项目：

国家自然科学基金资助项目（No. 81072342）

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