Abstract: Objective To analyze the risk factors of delayed healing of abdominal postoperative incision in patients with portal hypertension. Methods Clinical data of 228 cases of posthepatitic cirrhosis with portal hypertension were analyzed retrospectively. Cases of delated healing of incision were taken as observation group (95 cases) and incision healed well cases as control group (133 cases). The influencing factors of postoperative delayed healing of incision were screened and analyzed. Results Incidence rate of delated healing of incision was 41.67%. In observation group, the infection of incisional wound occured on 29 cases (1.27%), the fat liquefaction of incision on 60 cases (26.32%), the disruption of wound on 6 cases (2.63%). The influencing factor included with or without emergency operation, fat thickness, Child-Pugh classification, hyperfunction degrees of the spleen, operation time, volume of blood loss and power of the electrotome between two groups were statistically significant (P all ＜ 0.05). Conclusions In addition to subcutaneous fat thickness, power of the electrotome, operation time, delayed healing of abdominal postoperative incision in patients with portal hapertension is also influenced by the liver function status and splenic function of perioperative patients.