Abstract: Objective To evaluate the clinical effect of near-infrared wave in the assisted treatment of chronic hepatitis B and associated cirrhosis. Methods Total of 54 cases with chronic hepatitis B were randomly divided into two groups, 27 cases in each group; 12 patients with cirrhosis were randomly divided into two groups, 6 cases in each group. Patients in two groups were given the antiviral and hepatoprotective treatment, and patients in treatment group were also applied with near-infrared wave at the same time, the efficacy of the two groups were analyzed. Results For chronic hepatitis B patients, the periods of hospitalization and symptom improvement between the treatment group and control group were significantly different (P = 0.041, 0.015) but there is no significant difference on period of ALT recovery (P = 0.082); alos with significant differences in white blood cells count, hemoglobin concentration, HBsAg titer (P = 0.560, 0.471, 0.520); and the platelet was significantly higher after in treatment group (P = 0.001). For cirrhosis patients, the group treated with near-infrared wave was compared with the control group, there were significant differences in the periods of hospitalization and ALT recovery (P = 0.021, 0.023); also with significant differences in white blood cells count, hemoglobin concentration, HBsAg titer (P = 0.721, 0.562, 0.895); and the platelet was significantly higher in treatment group (P = 0.012), but there is no significant difference on period of symptom improvement (P = 0.075). Conclusions There is a certain clinical effect for near-infrared wave in the treatment of patients with hepatitis B and cirrhosis, which can be taken as a mean of assisted therapy.