Abstract: Objective To explore the different dosages of ADV for the treatment of chronic hepatitis B (CHB) patients after drug withdrawal hepatitis incidence and reason for discontinuation. Methods Total of 635 cases of different dosages of ADV therapy in patients with CHB liver meritorious service is regular detection, HBV DNA and build Excel follow-up system, compare each withdrawal hepatitis incidence. Results Half a set of drug withdrawal hepatitis 14.2%, constant withdrawal hepatitis was 13.7%, 1.5-2 times the amount of drug withdrawal hepatitis group 12.5%-16.2%, united group of drug withdrawal hepatitis, 19.3%; Each group accumulative total withdrawal hepatitis, 91 cases (14.3%), drug cessation related hepatocellular carcinoma 2 cases, 3 cases of severe hepatitis, 4 cases died. Conclusions Main reason for the discontinuation is effect is not satisfied with 46.1% and 21.9% economic difficulties, 13.1% antiviral awareness is not enough. The drug withdrawal hepatitis incidence of 2 times the amount group and combined treatment group was higher than constants group but no statistical difference. Obviously strengthen health education and doctor-patient communication, improve disease awareness, regular check and optimize treatment is the key to prevent withdrawal hepatitis and the related events.