Abstract: Objective To evaluate the clinical effect difference between blood purification combined with medical conventional treatment and simple drug treatment for group attack of severe mushroom poisoning patients. Methods Compared with blood purification treatment (including molecular adsorption recirculation system, plasma exchange, hemodialysis, hemofiltration, hemoperfusion and other technology) joint with conventional medical treatment and simple drug medical treatment on 64 severe mushroom poisoning patients. Clinical manifestations, laboratory examination, treatment effect and prognosis were retrospecively analyze. Results Severe mushroom poisoning patients often have liver, kidney, respiration, circulation, nerve system, enteron, clotting etc multiple organ dysfunction. Acute physiology and chronic health evaluation (APACHE Ⅱ score) showed, with the score increases, the mortality increasing. Total of 40 patients on the basis of conventional treatment combined with blood purification, cured 30 cases, the cure rate is 75%, while 24 patients with simple drug treatment, cured 6 cases, the cure rate is only 25%. Combined treatment group was obviously higher than that of pure drug therapy group (P ＜ 0.01). After blood purification, ALT, AST, TBil, DBil, GLB, Bun, HBDH, PT levels were significantly reduced than before blood purification (all P ＜ 0.05), while ALB, TD, Cr, CK, CKMB have fallen, but no significantl difference (all P ＞ 0.05). Conclusions Severe mushroom poisoning patients with the more viscera damage, the more mortality increased. Blood purification treatment for these patients have definite therapy effect to the benefit of remove toxins, reduce toxins absorption, relieve liver and kidney damage, improve coagulation function to make for patients through crisis. According to the state of illness, early blood purification treatment can obvious improve prognosis, improve the survival rate, reduce mortality.