Abstract: Objective To observe the effect of Yanbinfuzheng capsule against HBV virological indicators by boosting the immune system of patients. Explore the clinical efficacy of traditional Chinese medicine treatment on reducing the HBsAg, HBeAg virus titer and the splenomegaly of hepatitis B disease. Methods Total of the patients were randomly assigned to a treatment group (n = 23) that received Yanbinfuzheng capsule, or to a protocol group (n = 21). The control group alone had Yanbinfuzheng capsule, 5 capsules once time, 3 times once day; the protocol group received 10 mg adefovir dipivoxil once day, in addition, the treatment group received liver function improvement medicine such as Fufangniutaigan according to their situation; however, the treatment group had no such medicine during the clinical trial. Patients in both groups were treated for 48 weeks. Results Groups were similar with respect to demographics, admission criteria, operation type, and other variables. The treatment group had significantly lower HBsAg (P ＜ 0.05) and HBeAg (P ＜ 0.01) after the treatment. Conclusions The results showed that solely use of medicine Yanbinfuzheng capsule enables HBsAg, HBeAg HBV DNA splenomegaly load reduction.