Abstract: Objective To assessment the value of acoustic radiation force impulse (ARFI) and serological diagnosis model (Forns index, FIB-4, APRI) to liver fibrosis of chronic hepatic B. Methods Total of 111 patient confirmed as CHB, divided into groups according to the result of the liver biopsy: no significant liver fibrosis group (S0, S1) 40 cases, significantly fibrosis group (≥ S2) 48 cases, early cirrhosis group (S4) 23 cases. During the same period, each patient with the assessment of ARFI, Forns index, Fib-4 and APRI. Compared the correlation of noninvasive diagnosis model and liver biopsy. Moreover, analysis the diagnostic value of noninvasive liver fibrosis model to the liver fibrosis according to the receiver-operating characteristic curve. Results ARFI, Forns index, FIB-4, APRI, the four kinds of noninvasive diagnostic method has a good consistency with liver biopsy, and their Pearson correlation coefficient were 0.882, 0.639, 0.589, 0.418. The assessment value of ARFI to significantly fibrosis group (≥ S2) was superior to FIB-4 (Z = 2.882, P = 0.004; Z = 3.215, P = 0.001), APRI (Z = 4.850, P ＜ 0.001; Z = 3.198, P = 0.001), Forns index (Z = 2.182, P = 0.029; Z = 2.798, P = 0.005). Conclusions The assessment value to significantly fibrosis and early cirrhosis of ARFI is higher than others and worthy of promotion.