Abstract: Objective To investigate a quantitative assessment of hepatic functional reserve using flow cytometric analysis of asialoglycoprotein receptors (ASGPR) on the liver cell surface and regular clinical indexes. This assessment method was compared with the Child-Pugh score to evaluate its predictive value for hepatic functional reserve in patients undergoing liver resection or devascularization. Methods Total of 32 patients with liver tumors had partial hepatectomy. The percentage of the ASGPR+ hepatocyte (PHCASGPR+), ICGR15, effective hepatic blood flow (EHBF), the R value, the K value and regular clinical parameters were examined to evaluate a quantitative assessment method for liver functional reserve. The PHCASGPR+ was defined as a dependent variable (Y) while the other indexs were defined as independent variables (Xn). The accuracy of predicted postoperative liver compensation was obtained from follow-up information and was compared to that predicted by the Child-Pugh score. Total of 46 patients had partial hepatectomy or devascularization. The hepatic functional reserve was calculated with the new scoring system. The accuracy of predicted postoperative liver compensation was obtained from follow-up information and was compared to that predicted by the Child-Pugh score. Results The new scoring system (the Y value) had better accuracy in predicting postoperative hepatic functional reserve than Child-Pugh score (P = 0.030), but there were no statistical difference in predicting postoperative hepatic decompensation (P = 1.000). Conclusions The quantitative assessment method for hepatic functional reserve, established in the current study, could provide a comprehensive evaluation of perioperative hepatic functional reserve in some degrees in patients undergoing hepatectomy or devascularization.