Abstract: Objective To summarize the clinical characteristics of the liver disease of nasal bleeding, prone factors, to explore the clinical treatment and preventive measures of the right. Methods Retrospective analysis of 500 cases of liver disease cases of nasal bleeding, summarizes relevant factors, put forward points for attention and communicate diagnosis and treatment experience. Results Of 500 patients with nasal bleeding, bleeding common with Little ‘s area is 53.4%, 75% combined liver cirrhosis and liver cancer, 61% repeated bleeding, thrombocytopenia and coagulation function disorder nasal bleeding incidence was 70.6%. Conclusions High incidence of liver disease patients with nasal bleeding, and the nasal mucous membrane is dry, thrombocytopenia and blood coagulation dysfunction is closely related to the incidence of patients with advanced liver disease increased obviously. Nasal moisturizing care and nasal cavity filling is still as the main means of control.