Abstract: Objective To investigate the etiology, clinical features, treatment and its efficacy of drug-induced liver injury in order to improve clinical doctors understanding of this problem. Methods Seventy four cases of hospital patients with drug-induced liver injury were divided into UDCA group and without UDCA group, whose etiology, liver function and treatment outcome were retrospectively analyzed and whose liver function were assessed two weeks after treatment. Results A wide variety of drugs can cause liver damage, the most were traditional Chinese medicine (59.46%), followed by anti-inflammatory drugs (18.92%), and then were anti-TB drugs (8.11%) and Mongolian drug (4.05). Conventional liver protecting treatment was effectively, and UDCA group showed better efficacy. Conclusions Drug-induced liver injury was closely related to regional differences and drug variety. The efficacy of UDCA group in the treatment of drug-induced liver injury were significant.