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奥曲肽治疗肝硬化上消化道出血的疗效观察

作者：王芳梅唐中权

关键词：肝硬化胃肠道奥曲肽垂体激素类后叶治疗学

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出版年,卷(期):页码：2014,6(2):47-49

摘要：

摘要：目的探索肝硬化上消化道出血（UGH）的有效治疗药物。方法选择79例肝硬化UGH患者，临床采用随机分组的方式分为观察组（42例）和对照组（37例）。两组患者在输血、补液、抑酸剂、预防感染、抗肝性脑病、维持水电解质与酸碱平衡等治疗基础上，观察组应用奥曲肽0.1 mg静脉推注后，给予50 μg/h持续静脉输注；对照组给予垂体后叶素20 U静脉推注后，给予0.5 U/min持续静脉输注。结果观察组和对照组患者显效率为64.3%和37.8%（P = 0.0086），总有效率为95.2%和78.4%（P = 0.0228）。结论奥曲肽是治疗肝硬化UGH的安全、有效的药物。

Abstract: Objective To observe the effect of octreotide on upper gastrointestinal hemorrhage (UGH) in patients with liver cirrhosis. Methods Total of 79 cases of UGH patients were randomly divided into treatment group and control group. The two groups were defined on the basis of the internal medical treatment, 37 patients in the control group, were treated with pituitrin, 42 patients in the treatment group, were treated with octreotide. Results The difference of efficiency in two groups is significant 37.8% and 64.3% (P = 0.0086). Total effective rates were 78.4% and 95.2% (P = 0.0228), respectively. Conclusions Octreotide was safe and effective for the treatment of UGH in patients with liver cirrhosis.

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