Abstract: Objective To explore the clinical characteristics and therapeutic efficacy of retinopathy in acquired immunodeficiency syndrome (AIDS) merged with chronic hepatitis B (CHB). Methods Total of 65 cases with AIDS merged with CHB was examined by indirect ophthalmoscopy, and the eye symptom, fundus change, CD4+ T cell count, therapia and turnover of patients with retinopathy were analyzed. Results The retinopathy was including cottonwool patches (29 cases), hemorrhage (12 cases), ascellum vascellum (6 cases), cytomegalovirus retinitis (16 cases) and panuveitis (2 cases). The CD4+ T lymphocyte count was lower than 200 cells/μl mostly (93.8%), while the morbidity rised with the descended CD+4 T lymphocyte count. After therapy, the cottonwool patches and hemorrhage resolved in three months, while the effective rate of cytomegalovirus retinitis (CMVR) was 81.3%, but 4 cases recurred in three to four weeks after withdrawal. Conclusions The main characteristics of retinopathy in AIDS merged with CHB are cottonwool spot, hemorrhage, ascellum vascellum and CMVR, mostly appear in patients with lower CD4+ T lymphocyte count, increased incidence along with CD4+ T cell count reduced. AIDS with CHB patients should be examined by ophthalmology examination routinely, which is important for early diagnosis and treatment of retinopathy.