Abstract: Objective To analyze the effect of combined using different hemostatic drugs to treat liver cirrhosis with upper gastrointestinal hemorrhage. Methods From November 2010 to November 2013, 304 patients of liver cirrhosis with upper gastrointestinal hemorrhage were randomly divided into treatment group (152 cases) and control group (152 cases). Two groups were given medical conventional treatment of gastrointestinal bleeding (including resistance to infection, fluid infusion, protecting liver and psychotherapy). On this basis, the treatment group was given octreotide, tranexamic acid, hemocoagulase and pantoprazole intravenous drip to stop bleeding and expectant treatment. And the control group was given octreotide, omeprazole and p-aminomethyl benzoic acid intravenous drip, vitamin K and adrenochrome semicarbazone intramuscular injection, and lyophilizing thrombin powder oral for hemostasis treatment. Results Total effective rate of treatment group was 98.68% and control group was 86.84%, two groups showed statistically significant (P = 0.0001). Conclusions Internal medicine empirical comprehensive application can effectively treat liver cirrhosis with upper gastrointestinal hemorrhage, improve the cure rate, reduce mortality, economic efficiency, worth clinical promotion.