Abstract: Objective To explore the clinical significance of the relationship between the change of platelet parameters and liver cirrhosis after hepatitis B. Methods Total of 135 cases with liver cirrhosis after hepatitis B (group A) and 82 cases with healthy physical examination (group B) were detected for platelet count (PLT), thrombocytocrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW). According to gastrointestinal bleeding, the patients were divided into group A combination of upper gastrointestinal hemorrhage group (group C, 65 cases) and supreme gastrointestinal bleeding group (group D, 70 cases), each parameter were compared. Results PLT, PCT of group A were significantly lower than that of group B (P = 0.006), its MPV and PDW were higher than that of group B (P = 0.007). PLT, PCT, MPV and PDW of group C were lower than that of group D (both P ＜ 0.05). Conclusions Determination of platelet parameter to assess liver function damage in patients with cirrhosis, determine presence of bleeding tendency has important guiding significance.