Abstract: Objective To observe of liver stagnation and spleen deficiency, bruising internal resistance of clinical efficacy of hepatitis C liver cirrhosis treated by combination of traditional Chinese and Western medicine. Methods We collected 136 hepatitis C patients with cirrhosis in our hospital from January 2012 to February 2014 and make a retrospective analysis of clinical data. This patients randomly, equally divided into treatment group and routine group. Routine group treated with conventional Western medicine therapy, while treatment group add with Sophora reconciliation poison liver decoction treatment on the basis of routine group, and then observed the clinical efficacy of two groups of patients. Results Treatment group total effective rate reached 82.35%, routine group 60.29%, the clinical efficacy of the treatment group was significantly better than the routine group (P ＜ 0.05), and treatment group curative effect was more stable after six months. Conclusions The combination of traditional Chinese and Western medicine treatment of hepatitis C cirrhosis can effectively improve patient quality of life, gain significant clinical curative effect, is worthy of popularization and application.