Abstract: Objective To research the effect factors of postpartum hemorrhage of puerpera with liver diseases, and to propose corresponding preventive measures regarding to these relevant risk factors. Methods Total of 96 cases of puerpera in our hospital between January 2010 and December 2012 were selected, from which, 98 cases postpartum hemorrhage of puerpera with liver diseases were and were selected as experimental group, meanwhile 96 cases puerpera without postpartum hemorrhage were selected as control group. Then all the possible factors that may contribute to postpartum hemorrhage of puerpera were compared and analysed. Results Univariate analysis showed that postpartum hemorrhage of puerpera with liver diseases were related to that total protein, packed cell volume (Hct), blood platelet (PLT), albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood transfusion, hemoglobin. Multivariate analysis showed that the increasing of alanine aminotransferase (ALT) was independent risk factor of postpartum hemorrhage of puerpera with liver diseases, while the increasing of PLT was independent protective factor of postpartum hemorrhage of puerpera with liver diseases. Conclusions ALT and PLT were independent risk factors of postpartum hemorrhage of puerpera with liver diseases. These risk factors should be targeted prevention and control measures.