Abstract: Objective To clarify the relationship between liver stiffness and nutritional status of patients with chronic liver disease. Methods Liver stiffness of 205 hospitalized chronic liver disease patients were measured by transient elastography (FibroScan), and these patients were divided into four groups with different stage of liver fibrosis. Nutritional risk screening (NRS 2002) was applied to evaluate the nutrition risk of different groups of patients. Subjective global nutritional assessment (SGA) was used to determine the nutrition status of these patients. The relationship was analyzed with Spearman rank correlation. Results NRS 2002 screening showed that nutrition risk increased, nutrition status decreased when the liver fibrosis stage was getting severe, and the values of grasping power (HG), the triceps skinfold thickness (TSF), upper-arm circumference (MAC), prealbumin (PA), albumin (ALB) and total lymphocyte count (TLC) also declined, these differences were significant (P ＜ 0.05). The liver stiffness values of cirrhotic patient with more nutrition risk were higher than those with less nutrition risk, whereas the same result wasn’t observed in hepatitis patients. Conclusions There was difference in nutrition status among chronic liver disease patients with different liver stiffness, and increased nutrition risk or malnutrition might relate to liver stiffness.