Abstract: Objective To analysis and explore the clinical features of hepatic veno-occlusive disease (HVOD) induced by gynura segetum in the patients with alcoholic liver cirrhosis. Methods The data was collected and analysed from 4 patients hospitalized in our department from October 2012 to June 2014. The diagnosis of HVOD for all the patients was made by the drug use history, typical clinical manifestation, biochemical and iconographic examination, CT or MRI. Results The results showed that this group of cases has the following clinical features: all patients are male and the age was elder than 45 years old; all patients with history of long-term use of gynura segetum, one of Chinese medical herbs, because of the suffering orthopaedic disease such as fractures, lumbago, lumbar disc. Before the occuring of HVOD paroxysm, all of the patients had basis of alcoholic liver cirrhosis, with the average of 10 years of alcohol-drinking. All the cases manifested the typical clinical symptoms and sign of HVOD, but without hepatomegaly. The diagnosis of HVOD in all of patients was finally confirmed by both of CT or MRI and Inferior vena cava angiography. There was a positive relationship between the severity of the disease and the total dose of gynura segetum. Conclusions Long-term alcohol drinking may be an important risk factor for the severity of HVOD induce by gynura segetum. It is the first report of hepatic veno-occlusive disease induced by gynura segetum on the basis of alcoholic liver cirrhosis.