Abstract: Objective To observe the clinical effect and safety of Jianpiqinghua method combined with adefovir dipivoxil (ADV) on treating chronic hepatitis B (CHB). Methods Total of 158 cases with CHB were randomly double-blind divided into treatment group (n = 80, using ADV combined with Jianpiqinghua apozem) and control group (n = 78, only using ADV). Two groups were given conventional liver protection, suit the case and supportive treatment. The treatment lasted 24 weeks. Clinical symptoms, liver function and HBV DNA changes were observed before and treatment in patients. Results After treatment, the clinical symptoms, liver function and HBV DNA undetectable ratio of treatment group were better than that in control group (P ＜ 0.05). Conclusions Jianpiqinghua method combined with ADV is safe and effective treatment on CHB.