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41例伴肝功能受损的先天性胆总管囊肿手术前后肝功能变化及术式分析
作者:卢明珠 陈晓滨 
单位:厦门大学附属中山医院 普外儿外科 
关键词:先天性胆总管囊肿 手术方式 
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出版年,卷(期):页码:2015,7(1):73-76
摘要:

摘要:目的 探讨先天性胆总管囊肿的临床手术方法对肝功能改善的作用及其长期疗效的分析。方法 回顾性研究2009年9月至2013年12月手术治疗的先天性胆总管囊肿患者41例,其中男性23例,女性18例,年龄1.5~14岁。所有病例均经影像学确诊后行囊肿及胆囊切除、肝总管-空肠Roux-Y吻合术。术前、术后1周分别测定血清肝功能指标[TBil、直接胆红素(DBil)、ALT、AST]进行比较。结果 41例患者术前检测TBil和DBil,其中27例术前高于正常值,其术后TBil和DBil值较术前显著下降,差异有统计学意义(P < 0.01);另外14例在正常参考值范围内,其术后TBil和DBil值较术前差异无显著性(P > 0.01);两者术前ALT和AST指标均高于正常值,且术后均明显下降,术前术后比较差异有统计学意义(P < 0.01)。长期随访37例预后良好。2例患者术后肝胆管结石伴胆管炎,两次手术经原吻合口处切开取石后缓解。其中1例伴有左肝外叶纤维化,予切除部分左肝。2例患者在术后早期出现了并发症,1例出现急性胰腺炎,1例出现肠黏连肠梗阻,经保守治疗后均缓解。结论 囊肿及胆囊切除、肝总管-空肠Roux-Y吻合术,是治疗先天性胆总管囊肿的最佳手术方法。

Abstract: Objective To investigate the effect of clinical surgical techniques of congenital choledochal cyst on improving liver function and its long-termed effect. Methods We selected 41cases, including 23 males and 18 females, aged 1.5-14 years old, who are suffering from congenital choledochal cyst in Setemper 2009 to December 2013. All the patients were operated on with complete cyst excision combined with Roux-en-Y hepaticojejunostomy after diagnosis by imaging tests. The serum indexes of liver function, total bilirubin (TBil), direct bilirubin (DBil), alanine aminotransferase (ALT), aspartate aminotransferase (AST) before operation were tested to compared with that of one week after operation. Results The result of experiments shows that 27 cases of 41 patients were higher than normal in TBil and DBil, which decreased significantly after the procedure (P < 0.01), the difference means something in statistics. In addition, 14 cases are within the range of normal reference value, their postoperative TBil and DBil shows no significant difference (P > 0.01). Their preoperative ALT and AST indexes were higher than the normal value, which significantly decreased after the operation. There are significant differences between preoperative and postoperative surgery (P < 0.01). Thirty-seven cases which are visited regularly have good prognosis. Two patients suffered from stone formation in bile duct with cholangitis, and their symptoms were relieved after reoperation of lithotomy through original anastomosis, one of them received Partial resection of the left liver with the left lateral lobe of liver fibrosis. Among them there were two case with early postoperative complication, one case acute pancreatitis and the other case of adhesion ileus, both of them were relieved after conservative treatment. Conclusions We draw a conclusion that complete cyst excision combined with Roux-en-Y hepaticojejunostomy is the best surgical method to cure patients suffering from congenital choledochal cyst.

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