Abstract: Objective To observe the effect of interventional therapy guided by ultrasound in AIDS patients with liver abscess. Methods Clinical data about 17 patients of AIDS with liver abscesses (31 lesions) who underwent interventional therapy guided by ultrasound in our department from October 2009 to January 2014 were retrospectively analyzed. Results There are 31 abscesses among the 17 patients, single abscess in 9 cases, and multiple abscess in 8 cases. We punctured 16 abscesses and catheterized 15 abscesses with a success rate of 100%, the range of drainage time was 6-30 days. There was no medical staff exposed infection and definite complication with patients. All the patients were cured. One patient with a new abscess was punctured again after 3 months. Conclusions Interventional therapy with ultrasound guided is safe and effective for AIDS patients with liver abscess, also is the preferred treatment.