Abstract: Objective To analyze the characteristics of the occurrence of nosocomial infection in patients with fulminant hepatitis and help to effectively prevent the occurrence of hospital infection. Methods We used SPSS 13.0 statistical software for January 2009 to December 2013, 386 cases of hospital infection in severe hepatitis cases were retrospectively analyzed. Results There were 386 cases and 71 cases of hospital infection occurred in patients with severe hepatitis, hospital infection rate was 18.39%. The infection is given priority to with abdominal cavity infection, respiratory tract infection, intestinal infection. Pathogens to pneumonia Klebsiella bacillus, E. coli and the most common white candida. Hospital infections occur with age, length of hospital stay, invasive operation and application of antimicrobial agents positive correlation (P < 0.05). Hospital infection is given priority to with abdominal cavity infection, respiratory infections and gastrointestinal infection, the case fatality rate of 71.83%. Conclusions Fulminant hepatitis is high incidence of hospital infection, hospital infection of high-risk groups and lead to the risk factors of death.