Abstract: Objective To investigate the psychological condition and nursing intervention methods in patients with alcoholic liver disease combined withdrawal syndrome. Methods We use the self-assessment lists of symptom scale (SCL-90), anxiety self-assessment (SAS) and depression self rating scale (SDS) in 50 patients with chronic severe hepatitis is evaluated, the country give corresponding nursing intervention for psychological problems, assess again after intervention, the assessment result of intervention before separately with the national norm, the evaluation results after nursing intervention. Results Alcoholic liver disease combined withdrawal syndrome patient intervention before the SCL-90, SAS and SDS scores were higher than the national norm, with very significant difference (P ＜ 0.01). Score comparison difference before and after the intervention has very significant (P ＜ 0.01). Aware of knowledge about patients’ health at discharge was significantly better than on admission (P ＜ 0.05). Conclusions Take positive and effective clinical nursing interventions that can make withdrawal syndrome patients overcome negative psychological emotional response, effectively improve the psychological condition, improve the treatment compliance, promote symptom improvement and rehabilitation of disease.