Abstract: Objective To investigate the changes of coagulation function in patients with chronic liver disease. Methods Total of 97 cases with various types of chronic hepatitis measure prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB) with the healthy control group for comparison. Results Chronic hepatitis, cirrhosis patients with PT, APTT, TT were significantly prolonged (P ＜ 0.01), the content of FIB was decreased (P ＜ 0.01), chronic alcoholic liver disease, drug induced liver injury in patients with PT, APTT significantly prolonged (P ＜ 0.01), there were no significant difference between TT and FIB content (P ＞ 0.05). Conclusions Coagulation tests have a high reference value to monitor patients with bleeding tendency, guide clinical treatment and evaluate prognosis.