Abstract: Objective To investigate the epidemiological and clinical characteristics of patients infected with hepatitis E virus (HEV) in Chengdu from 2011 to 2013. Methods A retrospective analysis was conducted to investigate 98 patients with HEV infection in our hospital from January 2011 to December 2013 in terms of epidemiological and clinical characteristics. Results Among the 98 patients aged 9 years to 79 years, 63.27% of the cases were young adults (20-50 years old), and male patients numbered more than female ones (1.88∶1). Hepatitis E virus infection occurred throughout the year. The most patients were unemployed or retired residents, workers and peasants, and some were with basic diseases. Examination showed significantly increased level of serum transaminase and bilirubin. After pathogen identified by pharyngeal swab, anti-HEV-IgM and anti-HEV-IgG double-positive was confirmed in 48 patients. After treatment, 71 patients (71.45％) were cured, 25 patients (25.51％) were improved, and 2 patients died (2.04%). There was an old female patient deferred longer than one year. Conclusions The incidence of HEV is related to age, season, profession and basic diseases. Except for few chronicity, early insulation and effective treatment measures may lead to favourable prognosis.