Abstract: Objective To investigate the early diagnosis and treatment methods of acute fatty liver of pregnancy. Methods The clinical data of 23 patients with AFLP delivered from January to October 2014 in Beijing Ditan Hospital affiliated to the Capital Medical University were retrospectively analyzed. According to
bilirubin, the 23 patients were divided into two groups: ＞ 171 μmol/L for heavy group, ≤ 171 μmol/L for the light group, the complications of the two groups were statistical compared. Results The 23 cases of patients with acute fatty liver of pregnancy were significantly gastrointestinal symptoms. In addition to the higher bilirubin and blood coagulation disorders, laboratory tests showed that uric acid and lactate dehydrogenase were increased abnormally. The cases of renal insufficiency, pulmonary infection and hypoalbuminemia were compared in the bilirubin light group and bilirubin heavy group, P values were 0.023, 0.033 and 0.019, respectively, with statistical significance. P values of other complications were between 0.071 and 1.000, with no statistical significance. Conclusions Clinical symptoms, laboratory tests of uric acid and lactate dehydrogenase rise can be taken as reference indexes of the diagnosis of AFLP. Once diagnosed, pregnancy should be terminated, and multi-disciplinary integrated support treatment is the key to successful rescue. For high bilirubin patients, more attention should be paid to prevent infection.