Abstract: Objective To analyze the relationship between genotypes of rs12979860 on IL-28B and the antivirus effects in HCV infection patients. Methods The rs12979860 genotypes of 63 HCV infected patients who were admitted in Zhuhai People’s Hospital with IFN + RBV therapy were assayed and the anti-virus effects were also evaluated by HCV RNA quantitative real time PCR. The expression of rs12979860 genotype and antivirus effects were analyzed in our study. Results The genotypes of these 63 cases were 41 (65.1%) for C/C, 16 (25.4%) for C/T, and 6 (9.5%) for T/T. After treatment, there were totality 37 cases (58.7%) had rapid viral response (RVR), and 49 cases (77.8%) had sustained viral response (SVR). In genotype C/C there were totality 32 cases (78.0%) had RVR, and 37 cases (90.2%) had SVR. In genotype C/T there were totality 5 cases (31.2%) had RVR, and 11 cases (68.8%) had SVR . In genotype T/T there were 0 case had RVR and 1 case (16.7%) had SVR. The efficacy data showed statistically significant differences（P ＜ 0.01, P ＜ 0.05）. Conclusions
In hepatitis C patients that use IFN + RBV to anti-virus therapy, the RVR and SVR of C/C genotypes of rs12979860 is significantly better than C/T and T/T genotypes. Detect the genotypes of rs12979860 can predict the clearance of virus in anti-virus therapy and it is helpful to personality therapy for hepatitis C patients.