Abstract:　Objective　To discuss the clinical effects of Gexia Zhuyu Decoction Jiaweifang in patients with chronic hepatitis B cirrhosis. Methods Total of 126 patients with chronic hepatitis B cirrhosis in our hospital from June 2013 to May 2014 were selected and randomly divided into observation group and control group, 63 cases in each group. The observation group was treated with Gexia Zhuyu Decoction Jiaweifang combined with lamivudine, and the control group was treated with lamivudine only. Compared the clinical effects of the two groups. Results　The effective rate in the observation group was 82.5% (52/63), significantly higher than that in the control group [61.9% (39/63)], the difference was significant (P = 0.0097); there was no significant difference in AST, ALT, Child-Pugh, HA, LN, Ⅳ-C, and PⅢP before treatment in two groups (P ＞ 0.05), and the levels were significantly reduced after the treatment (the observation group：P= 0.0000, 0.0000, 0.0000, 0.0000, 0.0000, 0.0000, 0.0000；the control group：P = 0.0000, 0.0000, 0.0000, 0.0000, 0.0276, 0.0003, 0.0000), but the observation group was significantly lower than control group (P = 0.0000, 0.0000, 0.0000, 0.0127, 0.0287, 0.0000, 0.0164). Conclusions　Gexia Zhuyu Decoction Jiaweifang combined with lamivudine can improve the symptoms and signs based on the effective antiviral in patients with chronic hepatitis B cirrhosis, and reduce hepatic fibrosis index, promote the regeneration of liver cells, retard or reverse the process of hepatic cirrhosis.