Abstract: Objective To investigate the significance of interferon combined with adefovir dipivoxil (ADV) in the treatment of patients with chronic hepatitis B. Methods Chemiluminescence, PCR and continuous monitoring method were applied to detect HBsAg, HBV DNA and ALT levels of 60 patients with chronic
hepatitis B before and after the treatment of interferon combined with ADV, respectively. Also, the relationship between HBV DNA and HBsAg level was analyzed. Results Before treatment, HBV DNA level of 60 patients with CHB was (7.1 ± 0.6) log10 IU/ml, while HBsAg level was (3.5 ± 0.4) log10 IU/ml;
3 months after combined treatment of interferon and ADV, HBsAg, HBV DNA and ALT levels decreased; after combined treatment for 6 months, HBsAg and HBV DNA decreased significantly（P = 0.000）, and ALT level recovered to normal; 12 months later, the levels of HBsAg and HBV DNA were (2.1 ± 0.3) log10 IU/ml and (2.7 ± 0.3) log10 IU/ml, no patients occurred resistance. And there was a positive correlation between HBsAg and HBV DNA. Conclusions Combined treatment of interferon and ADV can significantly reduce the ALT level and improve the negative conversion rates of HBV DNA and HBeAg of patients with chronic hepatitis B. Regular detection of HBsAg is helpful to assess the curative effect, drug resistance and weather to prolong the course of ADV combined with interferon treatment for patients with chronic hepatitis B.