Abstract: Objective To observe the clinical characteristics and immune states of HBeAg positive and HBeAg negative patients with chronic hepatitis B (CHB). Methods Total of 234 patients were entolled. The sex, age, disease severity and the level of ALT, HBV DNA load, immunoglobulin (Ig), complement (C), t-lymphocyte subsets of the two groups were compared, respectively. Results The average age of HBeAg negative patients was older (F = 33.075, P = 0.000), the total bilirubin, HBV DNA and the proportion of severe liver damage were higher than those of HBeAg positive. The immune indexes above-mentioned had
no significant differences between two groups. Conclusions With older age and severer liver damage, HBeAg negative CHB patients should accept antiviral therapy more urgently. We may monitor the dynamic changes of HBsAg degrees, ALT and HBV DNA loads in order to predict the efficiency of antiviral therapy.