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青岛地区汉族人群190例NAFLD患者IL28B基因rs12979860及rs8099917多态性研究

作者：李江文 1 2 许新 1 2 董全勇 1 2 林中华 2 初蕾蕾 2 辛永宁 2 3 宣世英 2 3 4

单位：1. 大连医科大学大连 116044 2. 青岛市市立医院消化内二科青岛 266021 3. 青岛市消化疾病重点实验室青岛 266021 4. 中国海洋大学医药学院青岛 266003

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出版年,卷(期):页码：2015,7(3):59-63

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摘要：目的探讨青岛地区汉族人群IL28B基因rs12979860、rs8099917多态性与NAFLD的相关性。方法收集190例青岛地区汉族NAFLD患者和183例正常人的血液标本，采用多重高温连接酶检测反应技术（iMLDR）进行IL28B的基因分型。计数资料比较进行χ 2 检验，计量资料进行t检验，非条件Logistic回归模型计算比值比（OR）及其95%可信区间（CI）。结果 IL28B基因rs12979860、rs8099917位点基因型及等位基因在NAFLD 组与对照组中的分布频率差异无统计学意义（P ＞ 0.05）。相对于野生型rs12979860 CC型、rs8099917 TT型，含突变位点基因型未增加NAFLD的发病风险，经多变量Logistic回归分析计算后，含等位基因rs12979860 T、rs8099917 G的基因型携带者发生NAFLD的比值比（OR及95% CI ）分别为0.958（95% CI：0.517～1.776，P = 0.892）及0.959（95% CI：0.490～1.876，P = 0.903）。结论在青岛地区汉族人群中，IL28B基因rs12979860、rs8099917两位点基因多态性与NAFLD的发生无明显相关性。

Abstract: Objective To investigate the relationship between IL28B gene rs12979860, rs8099917 polymorphisms and nonalcoholic fatty liver disease (NAFLD) of Han population in Qingdao. Methods Blood samples of 190 patients of Han population in Qingdao with NAFLD and 183 healthy controls were analyzed and the IL28B genotypes were detected by improved multiple high temperature ligase detection reaction technology (iMLDR). Chi square test, t test, and logistic regression analysis were used in this study. Results The frequencies of IL28B gene rs12979860, rs8099917 genotypes and alleles had no significant
difference between the two groups. Compared with the wild CC genotype of rs12979860 and TT genotype of rs8099917, the genotypes containing mutation did not increase the risk of developing NAFLD. Logistic regression analysis showed that the OR of carriers with the TT + TC genotype of IL28B gene rs12979860 and GG+TG genotype of rs8099917 developing NAFLD were 0.958 (95% CI : 0.517～1.776, P = 0.892) and 0.959 (95% CI : 0.490～1.876, P = 0.903), respectively. Conclusions The two polymorphisms of IL28B gene are not associated with the development of NAFLD in the Han population in China.

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