Abstract: Objective To analyze the clinical features of primary hepatic carcinoma (PHC) with hepatitis B virus infection and to provide bases for the diagnosis and therapy of primary hepatic cancer. Methods Total of 398 cases of PHC in our hospital from January 2010 to January 2014 were collected, and 207 patients with all the information were divided into two groups, HBV-positive group and HBV-negative group, and data were analyzed, retrospectively. Results There were 306 males and 96 females and the sexy ratio was 3.15∶1. The age of the patients were between 34～88 years old, with the most aged between 41～70 years old. Of the totally 207 cases of PHC, the detection rate of hepatitis B virus was 60.4% (125 cases). AST and AFP of HBV-positive group were significantly higher than those of the HBV-negative group, but PLT and ages were lower than those of the HBV-negative group. Conclusions The hepatitis B virus infection is an important cause of the PHC. Patients with HBV infection emerged PHC earlier than patients without HBV infection. The level of AST, AFP and PLT is important for earlier detection of PHC. It is necessary to prevent and controll hepatitis B.